Bioinformatics is a discipline in itself, with a culture of its own. Staying abreast of the latest advances and bright ideas emerging in the field is challenging. In 2019, SIB Members contributed for instance to hundreds of publications, on a range of topics.To provide the global bioinformatics community with the 'must-reads' of the year by SIB Scientists, the SIB Remarkable Outputs were launched. This selection follows a rigorous process conducted by the SIB Award committee* incl. SIB Group Leaders and Researchers. Peer-reviewed publications as well as preprints, software tools, databases, videos, etc. are eligible. Discover them below:


  • CoalRe: A Framework for phylogenetic inference on reassortment networks
    Discover this Output
    Group involved: Computational Evolution, Zurich
    Related resources: PNAS paper ; in silico talk; tutorial
    What the committee said about the work: "Analyzing evolution in the presence of recombination and reassortment is one of the major open problems in phylogenetics. This is an original contribution to a very challenging computational problem."


  • Deciphering interaction fingerprints from protein molecular surfaces using geometric deep learning
    Discover this Output

    Group involved: Laboratory of Protein Design and Immunoengineering, Lausanne
    Related resources: tutorial; in depth review
  • What the committee said about the work: "A very nice approach to capitalize on machine learning to analyze protein structures.The bioinformatics approach developed is innovative and essential to developing effective therapeutics."


  • Enzyme annotation in UniProtKB using Rhea
    Discover this Output

    Group involved: Swiss-Prot, Geneva 
    Related resources: talk at the SIB Days 2020  
  • What the committee said about the work: "The shift from Enzyme Commission numbers to Rhea reactions is a huge step forward. There is little doubt that this will facilitate reuse and computational analysis of metabolic pathways and other reaction-based bioinformatics."



  • LEMMI: A continuous benchmarking platform for metagenomics classifiers
    Discover this
    Group involved: Computational Evolutionary Genomics, Geneva
    Related resources: Genome Research paper; preprint; webpage
  • What the committee said about the work: "The tool may become a great asset to microbial research. It allows to close the gap of metagenomic classifier benchmarks by offering a flexible, standardized framework."


The yearly SIB Remarkable Outputs focus on the achievements of the community of SIB Members, and are thus complementary to the SIB Awards, which are taking place every two years and single out scientists and resources at the national and international levels (meet the 2019 laureates).


*Selection committee: Amos Bairoch, Luciano Cascione, Christophe Dessimoz, Frédérique Lisacek, Charlotte Soneson, Andrzej Stasiak, Robert Waterhouse, Mihaela Zavolan