Around 20,300 protein-coding genes have been predicted from the analysis of the human genome. On the occasion of its tenth anniversary, the Human Proteome Project (HPP) reports the experimental validation of 90.4% of the human proteome at high stringency, a significant milestone. The publication highlights the role of the SIB Resource neXtProt as the reference knowledgebase of HPP.
“We are very proud to be part of this community-driven adventure to deepen our knowledge and understanding of human proteins through neXtProt. This is a remarkable achievement.” says Lydie Lane, co-lead author of the paper and Associate Group Leader at CALIPHO.
The next challenge of the HPP will be to understand the roles played by each of these proteins in human health and disease, and use this knowledge to improve our understanding, diagnosis and treatment of cancers, cardiovascular and infectious diseases.
Adhikari S et al. A high-stringency blueprint of the human proteome, Nature Communications, 2020.
Omen G S et al. Research on the human proteome reaches a major milestone: >90% of predicted human proteins now credibly detected, according to the HUPO Human Proteome Project, J. Proteome Res., 2020.