What we do
We aim to use a combination of bioinformatics and experimental methodologies to increase knowledge about the function of the 20,000 protein-coding genes in the human genome. Our main mission is the development of neXtProt, a human protein knowledge resource. We also annotate the effects of human protein variations in the context of cancers and genetic diseases. We are part of the HUPO Human Protein Project, which aims to validate the existence of all predicted human proteins in biological samples by mass spectrometry. We are active in the development of ontologies/standardization resources such as the Cellosaurus and ICEPO.
Find out about the Group’s activities
Press coverage
«Toutes les espèces animales multicellulaires peuvent générer des lignées» - Le Temps
Main publications 2020
- Adhikari S et al.
Share A high-stringency blueprint of the human proteome.
Nature Communications, 10.1038/s41467-020-19045-9 - Vandenbrouck Y et al.
The Functionally Unannotated Proteome of Human Male Tissues: A Shared Resource to Uncover New Protein Functions Associated with Reproductive Biology
J Proteome Res, 10.1021/acs.jproteome.0c00516 - Zahn-Zabal M and Lane L
The neXtProt knowledgebase in 2020: data, tools and usability improvements
Expert Review of Proteomics, 10.1080/14789450.2020.1733418
