We aim to use a combination of bioinformatics and experimental methodologies to increase knowledge about the function of the 20,000 protein-coding genes in the human genome. Our main mission is the development of neXtProt, a human protein knowledge resource. We also annotate the effects of human protein variations in the context of cancers and genetic diseases. We are part of the HUPO Human Protein Project, which aims to validate the existence of all predicted human proteins in biological samples by mass spectrometry. We are active in the development of ontologies/standardization resources such as the Cellosaurus and ICEPO.
The group develops the SIB Resource Cellosaurus, an expertly curated database on cell lines