What we do

We aim to use a combination of bioinformatics and experimental methodologies to increase knowledge about the function of the 20,000 protein-coding genes in the human genome. Our main mission is the development of neXtProt, a human protein knowledge resource. We also annotate the effects of human protein variations in the context of cancers and genetic diseases. We are part of the HUPO Human Protein Project, which aims to validate the existence of all predicted human proteins in biological samples by mass spectrometry. We are active in the development of ontologies/standardization resources such as the Cellosaurus and ICEPO.

Find out about the Group’s activities

Press coverage

«Toutes les espèces animales multicellulaires peuvent générer des lignées» - Le Temps

Main publications 2020

  • Adhikari S et al.
    Share A high-stringency blueprint of the human proteome.
    Nature Communications, 10.1038/s41467-020-19045-9
  • Vandenbrouck Y et al.
    The Functionally Unannotated Proteome of Human Male Tissues: A Shared Resource to Uncover New Protein Functions Associated with Reproductive Biology
    J Proteome Res, 10.1021/acs.jproteome.0c00516
  • Zahn-Zabal M and Lane L
    The neXtProt knowledgebase in 2020: data, tools and usability improvements
    Expert Review of Proteomics, 10.1080/14789450.2020.1733418


Zurich university waedenswil

Amos Bairoch & Lydie Lane
Computer and Laboratory Investigation of Proteins of Human Origin (CALIPHO)
Geneva, Centre Médical Universitaire (CMU)
Group Webpage

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Domain(s) of activity:

  • Proteins and proteomes
  • APIs
  • Database curation
  • Data management
  • Data mining
  • Data visualisation
  • Ontology
  • Proteomics
  • Semantic web format

Domain(s) of application:

  • Basic research