What we do

We aim to use a combination of bioinformatics and experimental methodologies to increase knowledge about the function of the 20,000 protein-coding genes in the human genome. Our main mission is the development of neXtProt, a human protein knowledge resource. We also annotate the effects of human protein variations in the context of cancers and genetic diseases. We are part of the HUPO Human Protein Project, which aims to validate the existence of all predicted human proteins in biological samples by mass spectrometry. We are active in the development of ontologies/standardization resources such as the Cellosaurus and ICEPO.

Main publications 2017

  • Hinard V et al. Annotation of functional impact of voltage-gated sodium channel mutations. Hum. Mutat. 2017; 38:485
  • Ommen GS et al. Progress on the HUPO Draft Human Proteome: 2017 Metrics of the Human Proteome Project. J. Proteome Res. 2017; 16:4281
  • Schaeffer M et al. The neXtProt peptide uniqueness checker: a tool for the proteomics community. Bioinformatics 2017; 33:3471

Find out more about the Group’s activities


Zurich university waedenswil

Amos Bairoch & Lydie Lane
Computer and Laboratory Investigation of Proteins of Human Origin (CALIPHO)
Geneva, Centre Médical Universitaire (CMU)
Group Webpage

Domains of activity:

  • Proteins and proteomes
  • Biochemistry
  • Biomarkers
  • Database curation
  • Data mining
  • Experimental biology
  • Knowledgebase
  • Personalised medicine
  • Proteomics
  • Systems biology
  • Text mining

Domains of application:

  • Medicine and health
  • Basic research