A team led by Joana Pereira and Torsten Schwede at the Biozentrum of the University of Basel and SIB have uncovered a treasure trove of uncharacterized proteins. Embracing the recent deep learning revolution and benefiting from a dedicated kickstarter grant from SIB, they discovered hundreds of new protein families, including a novel predicted protein fold. The study has now been published in the journal Nature, together with another study from the SIB Group of Pedro Beltrao at ETH on a related topic.
Durairaj J et al. Uncovering new families and folds in the natural protein universe. Nature. Published online 13 September 2023.
Barrio-Hernandez I et al. Clustering-predicted structures at the scale of the known protein universe. Nature. Published online 13 September 2023.