picture of Torsten Schwede

Computational Structural Biology

Torsten Schwede
University of Basel

In the Computational Structural Biology (CSB) Group, we focus on the development of methods and algorithms to model, simulate and analyse three-dimensional protein structures and their molecular properties in order to apply these techniques to the understanding of biological processes at a molecular level. Our main emphasis is on homology modelling – using evolutionary information to model protein tertiary and quaternary structures. Applications in biomedical research include the study of protein-ligand interactions, drug discovery, structure-guided protein engineering, and the interpretation of mutations related to diseases and drug resistance. 

The group develops the SIB Resource SWISS-MODEL, a protein structure homology-modelling suite of software tools and databases.

Domain(s) of application
Basic research
Environmental sciences
Medicine and health
Domain of activity
Structural biology