What we do

In the Computational Structural Biology (CSB) Group, we focus on the development of methods and algorithms to model, simulate and analyse three-dimensional protein structures and their molecular properties in order to apply these techniques to the understanding of biological processes at a molecular level. Our main emphasis is on homology modelling – using evolutionary information to model protein tertiary and quaternary structures. Applications in biomedical research include the study of protein-ligand interactions, drug discovery, structure-guided protein engineering, and the interpretation of disease-causing mutations.

The group develops the SWISS-MODEL tool.

Main publications 2018

  • Waterhouse A et al.
    SWISS-MODEL: homology modelling of protein structures and complexes.
    Nucleic acids res.
  • Haas J et al.
    Continuous Automated Model Evaluation (CAMEO) complementing the Critical Assessment of Structure Prediction in CASP12.
    Proteins
  • Studer G et al.
    Modeling of protein tertiary and quaternary structures based on evolutionary information.
    Methods Mol Biol.

Find out more about the Group’s activities

Members

University basel

Torsten Schwede
Computational Structural Biology Group
University of Basel
Group Webpage

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Domains of activity:

  • Structural biology
  • Benchmarking
  • Biophysics
  • Data management
  • Drug design
  • Drug resistance
  • Homology modelling
  • Protein engineering
  • Structural biology
  • Workflows

Domains of application:

  • Basic research
  • Medicine and health

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