What we do

In the Computational Structural Biology (CSB) Group, we focus on the development of methods and algorithms to model, simulate and analyse three-dimensional protein structures and their molecular properties in order to apply these techniques to the understanding of biological processes at a molecular level. Our main emphasis is on homology modelling – using evolutionary information to model protein tertiary and quaternary structures. Applications in biomedical research include the study of protein-ligand interactions, drug discovery, structure-guided protein engineering, and the interpretation of disease-causing mutations.

The group develops the SWISS-MODEL tool.

Main publications 2018

  • Waterhouse A et al.
    SWISS-MODEL: homology modelling of protein structures and complexes.
    Nucleic acids res, doi: 10.1093/nar/gky427
  • Haas J et al.
    Continuous Automated Model Evaluation (CAMEO) complementing the Critical Assessment of Structure Prediction in CASP12.
    Proteins, doi: 10.1002/prot.25431
  • Studer G et al.
    Modeling of protein tertiary and quaternary structures based on evolutionary information.
    Methods Mol Biol, doi: 10.1007/978-1-4939-8736-8_17

Find out more about the Group’s activities


University basel

Torsten Schwede
Computational Structural Biology Group
University of Basel
Group Webpage



Domain(s) of activity:

  • Structural biology
  • Benchmarking
  • Biophysics
  • Data management
  • Drug design
  • Drug resistance
  • Homology modelling
  • Protein engineering
  • Software engineering

Domain(s) of application:

  • Basic research
  • Medicine and health