What we do

In the Computational Structural Biology (CSB) Group, we focus on the development of methods and algorithms to model, simulate and analyse three-dimensional protein structures and their molecular properties in order to apply these techniques to the understanding of biological processes at a molecular level. Our main emphasis is on homology modelling – using evolutionary information to model protein tertiary and quaternary structures. Applications in biomedical research include the study of protein-ligand interactions, drug discovery, structure-guided protein engineering, and the interpretation of disease-causing mutations.

The group develops the SWISS-MODEL tool.

Main publications 2017

  • Bertoni M et al. Modeling protein quaternary structure of homo- and hetero-oligomers beyond binary interactions by homology. Sci Rep. 2017; 7: 10480.
  • Bienert  S et al. The SWISS-MODEL Repository - new features and functionality. Nucleic Acids Res. 2017; 45:D313-D319.
  • Haas  J et al. Continuous Automated Model Evaluation (CAMEO) Complementing the Critical Assessment of Structure Prediction in CASP12. Proteins, [Epub ahead of print].

Find out more about the Group’s activities

Members

University basel

Torsten Schwede
Computational Structural Biology Group
University of Basel
Group Webpage

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Domains of activity:

  • Structural biology
  • Benchmarking
  • Biotechnology
  • Data mining
  • Drug design
  • Homology modelling
  • Knowledgebase
  • Machine learning
  • Protein engineering
  • Protein interaction
  • Software engineering

Domains of application:

  • Medicine and health
  • Basic research
  • Biotechnology

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