What we do

In the Evolutionary Bioinformatics Group, we are mainly concerned with determining the role of evolutionary innovation and constraint in animals. For this, we develop methods and databases to extract reliable information from genome and transcriptome data. These include Bgee, a database for gene expression evolution, and Selectome, a database of positive selection. While developing these resources, we also conduct research on ontologies, biocuration, and high-performance computing. Our biological focus is to link Evo-Devo with phylogenomics. Notably, we study the role of gene duplication in the divergence between genes and between species.

Find out more about the Group’s activities

Main publications 2018

  • Komljenovic A et al.
    BgeeDB, an R package for retrieval of curated expression datasets and for gene list expression localization enrichment tests.
    F1000Res, doi: 10.12688/f1000research.9973.2
  • Liu J et al.
    Adaptive evolution of animal proteins over development: support for the Darwin selection opportunity hypothesis of Evo-Devo.
    Mol Biol Evol, doi: 10.1093/molbev/msy175
  • Liu J and Robinson-Rechavi M
    Developmental constraints on genomeevolution in four bilaterian model species.
    Genome Biol Evol, https://doi.org/10.1093/gbe/evy177

Members

epfl lausanne

Marc Robinson-Rechavi & Frédéric Bastian
Evolutionary Bioinformatics Group
University of Lausanne
Group Webpage

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Domains of activity:

  • Evolution and phylogeny
  • Comparative genomics
  • Database curation
  • Evo-Devo
  • Evolutionary biology
  • Gene regulation
  • Next generation sequencing
  • Ontology
  • Phylogenetic tree analysis natural selection
  • Training
  • Transcriptomics

Domain of application:

  • Basic research

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