What we do

In the Evolutionary Bioinformatics Group, we are mainly concerned with determining the role of evolutionary innovation and constraint in animals. For this, we develop methods and databases to extract reliable information from genome and transcriptome data. These include Bgee, a database for gene expression evolution, and Selectome, a database of positive selection. While developing these resources, we also conduct research on ontologies, biocuration, and high-performance computing. Our biological focus is to link Evo-Devo with phylogenomics. Notably, we study the role of gene duplication in the divergence between genes and between species.

Find out more about the Group’s activities

Main publications 2019

  • Parker DJ et al.
    Sex-biased gene expression is repeatedly masculinized in asexual females
    Nature communications, doi: 10.1038/s41467-019-12659-8
  • Komljenovic A et al.
    Cross-species functional modules link proteostasis to human normal aging
    PLoS comput biol, doi: 10.1371/journal.pcbi.1007162
  • Davydov II et al.
    Large-Scale Comparative Analysis of Codon Models Accounting for Protein and Nucleotide Selection
    Mol Biol Evol, doi: 10.1093/molbev/msz048

Members

epfl lausanne

Marc Robinson-Rechavi & Frédéric Bastian
Evolutionary Bioinformatics Group
University of Lausanne
Group Webpage

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Domain(s) of activity:

  • Evolution and phylogeny
  • Comparative genomics
  • Database curation
  • Evo-Devo
  • Evolutionary biology
  • Gene regulation
  • Next generation sequencing
  • Ontology
  • Phylogenetic tree analysis (natural selection)
  • Training
  • Transcriptomics

Domain(s) of application:

  • Basic research

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