What we do

Our main research interest in the Genome Systems Biology (GSB) Group is the study of genome-wide regulatory systems, in order to reconstruct them from high-throughput molecular data, understand and model how they have evolved, and search for design principles in their construction. In particular, we are developing and applying new algorithmic tools for the automated reconstruction of genome-wide regulatory networks from comparative genomic, deep sequencing, and other high-throughput data. In addition, methods are being developed for studying genome evolution, and the evolution of regulatory networks, in particular.

The group develops the SwissRegulon portal.

Main publication 2017

  • Omidi S et al. Automated incorporation of pairwise dependency in transcription factor binding site prediction using dinucleotide weight tensors. PLoS Comput biol. 13 (7), e1005176

Find out more about the Group’s activities


University basel

Erik van Nimwegen
Genome Systems Biology Group
University of Basel
Group Webpage


Domains of activity:

  • Genes and genomes
  • Comparative genomics
  • Population genetics
  • Epigenetics
  • Evolutionary biology
  • Gene regulatory network analysis
  • Next generation sequencing
  • Phylogeny
  • Systems biology
  • Transcriptomics
  • Gene regulation
  • Single-cell biology

Domains of application:

  • Medicine and health
  • Basic research