What we do

Our main research interest in the Genome Systems Biology (GSB) Group is the study of genome-wide regulatory systems, in order to reconstruct them from high-throughput molecular data, understand and model how they have evolved, and search for design principles in their construction. In particular, we are developing and applying new algorithmic tools for the automated reconstruction of genome-wide regulatory networks from comparative genomic, deep sequencing, and other high-throughput data. In addition, methods are being developed for studying genome evolution, and the evolution of regulatory networks, in particular.

The group develops the SwissRegulon portal.

Find out more about the Group’s activities

Publications 2019

  • Witz G et al.
    Initiation of chromosome replication controls both division and replication cycles in E. coli through a double-adder mechanism
    eLife, doi: 10.7554/eLife.48063
  • Sakoparnig T et al.
    Whole genome phylogenies reflect long-tailed distributions of recombination rates in many bacterial species
    bioRxiv, doi: 10.1101/601914
  • Breda J et al.
    Bayesian inference of the gene expression states of single cells from scRNA-seq data
    bioRxiv, doi: 10.1101/2019.12.28.889956


University basel

Erik van Nimwegen
Genome Systems Biology Group
University of Basel
Group Webpage


Domain(s) of activity:

  • Genes and genomes
  • Systems biology
  • Comparative genomics
  • Epigenetics
  • Evolutionary biology
  • Gene regulatory network analysis
  • Microbiology
  • Next generation sequencing
  • Phylogeny
  • Single-cell biology
  • Transcriptomics

Domain(s) of application:

  • Basic research
  • Medicine and health