What we do

In the Laboratory of Systems Biology and Genetics (LSBG), we use high-throughput sequencing, single cell genomics, microfluidics, and computational approaches

  1. to decipher the regulatory code in Drosophila and mammals with a specific focus on mesenchymal stem cell function, adipose biology and gut immunity, and
  2. to examine how variations in this code affect molecular and organismal diversity.

In addition to our research interests, we are actively pursuing the development of new research tools and computational pipelines that enable a better characterization of gene regulatory networks.

Main publications 2017

  • Schwalie PC et al. Cross-tissue identification of somatic stem and progenitor cells using a single-cell RNA-seq derived gene signature. Stem Cells, 35:2390-2402, 2017.
  • Gardeux V et al.  ASAP: a Web-based platform for the analysis and interactive visualization of single-cell RNA-seq data. Bioinformatics, 33:3123–3125, 2017
  • Isakova A et al. SMiLE-seq identifies binding motifs of single and dimeric transcription factors. Nat methods, 14:316-322, 2017

Find out more about the Group’s activities



Bart Deplancke
Laboratory of Systems Biology and Genetics
EPFL, Lausanne
Group Webpage


Domains of activity:

  • Gene and Genomes
  • Genome structure
  • Functional genomics
  • Microfluidics
  • Proteomics
  • Single-cell biology
  • Structural biology
  • Systems biology

Domain of application:

  • Medicine and health