What we do

In the Laboratory of Systems Biology and Genetics (LSBG), we use high-throughput sequencing, single cell genomics, microfluidics, and computational approaches:

  1. to decipher the regulatory code in Drosophila and mammals with a specific focus on mesenchymal stem cell function, adipose biology and gut immunity, and
  2. to examine how variations in this code affect molecular and organismal diversity.

In addition to our research interests, we are actively pursuing the development of new research tools and computational pipelines that enable a better characterization of gene regulatory networks.

Find out more about the Group’s activities

Main publications 2019

  • Alpern A et al.
    BRB-seq: ultra-affordable high-throughput transcriptomics enabled by bulk RNA barcoding and sequencing
    Genome Biology, doi: 10.1186/s13059-019-1671-x
  • Chen W et al.
    ZFP30 Promotes Adipogenesis Through the KAP1-mediated Activation of a Retrotransposon-Derived Pparg2 Enhancer
    Nature Communications, doi: 10.1038/s41467-019-09803-9
  • Bevers R et al.
    Mitochondrial haplotypes affect metabolic phenotypes in the Drosophila Genetic Reference Panel
    Nature Metabolism, doi: 10.1038/s42255-019-0147-3



Bart Deplancke
Laboratory of Systems Biology and Genetics
EPFL, Lausanne
Group Webpage


Domain(s) of activity:

  • Genes and genomes
  • Functional genomics
  • Gene regulatory network analysis
  • Gene regulation
  • GWAS
  • Human genetics
  • Machine learning
  • Microfluidics
  • Personalised medicine
  • Single-cell biology
  • Transcriptomics

Domain(s) of application:

  • Medicine and health