What we do

In the Laboratory of Systems Biology and Genetics (LSBG), we use high-throughput sequencing, single cell genomics, microfluidics, and computational approaches:

  1. to decipher the regulatory code in Drosophila and mammals with a specific focus on mesenchymal stem cell function, adipose biology and gut immunity, and
  2. to examine how variations in this code affect molecular and organismal diversity.

In addition to our research interests, we are actively pursuing the development of new research tools and computational pipelines that enable a better characterization of gene regulatory networks.

Find out more about the Group’s activities

Main publications 2021

  • Litovchenko M et al.
    Extensive tissue-specific expression variation and novel regulators underlying circadian behavior
    Science Advances, 10.1126/sciadv.abc3781
  • Li H et al.
    Fly Cell Atlas: a single-cell transcriptomic atlas of the adult fruit fly
    BioRxiv, 10.1101/2021.07.04.451050
  • Chen W et al.
    Genome-wide molecular recording using Live-seq
    BioRxiv, 10.1101/2021.03.24.436752



Bart Deplancke
Laboratory of Systems Biology and Genetics
EPFL, Lausanne
Group Webpage


Domain(s) of activity:

  • Genes and genomes
  • Systems biology
  • Biotechnology
  • Deep sequencing data
  • Epigenetics
  • Functional genomics
  • Gene regulatory network analysis
  • Gene regulation
  • GWAS
  • Human genetics
  • Machine learning
  • Metabolomics
  • Microfluidics
  • Next generation sequencing
  • Oncology
  • Personalised medicine
  • Single-cell biology
  • Transcriptomics

Domain(s) of application:

  • Medicine and health