What we do

In the Laboratory of Systems Biology and Genetics (LSBG), we use high-throughput sequencing, single cell genomics, microfluidics, and computational approaches:

  1. to decipher the regulatory code in Drosophila and mammals with a specific focus on mesenchymal stem cell function, adipose biology and gut immunity, and
  2. to examine how variations in this code affect molecular and organismal diversity.

In addition to our research interests, we are actively pursuing the development of new research tools and computational pipelines that enable a better characterization of gene regulatory networks.

Main publications 2018

  • Schwalie PC et al.
    A stromal cell population that inhibits adipogenesis in mammalian fat depots.
    Nature, doi: 10.1038/s41586-018-0226-8
  • Wang QA et al.
    Reversible de-differentiation of mammary adipocytes into adipose precursor-like cells during lactation.
    Cell Metab, doi: 10.1016/j.cmet.2018.05.022

Find out more about the Group’s activities



Bart Deplancke
Laboratory of Systems Biology and Genetics
EPFL, Lausanne
Group Webpage


Domain(s) of activity:

  • Genes and genomes
  • Functional genomics
  • Gene regulatory network analysis
  • Gene regulation
  • GWAS
  • Human genetics
  • Machine learning
  • Microfluidics
  • Personalised medicine
  • Single-cell biology
  • Transcriptomics

Domain(s) of application:

  • Medicine and health