What we do

In the Host-Pathogen Genomics Group, we explore the genetic roots of inter-individual differences in response to infections, with a particular focus on the genomic interactions between pathogens and their human hosts. At the crossroads between basic science and the clinical world, we are committed to translational genomic research, aimed at identifying, validating and bringing to clinical use genetic markers of susceptibility to infectious diseases – e.g. host genomics of HIV infection, joint analyses of interactions between human and viral genomes, and exome sequencing on patients with extreme infectious disease phenotypes.

Main publications 2018

  • Scepanovic P et al.
    Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines.
    Genome Med, doi: 10.1186/s13073-018-0568-8
  • Patin E et al.
    Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors.
    Nat Immunol, doi: 10.1038/s41590-018-0049-7
  • Naret O et al.
    Correcting for population stratification reduces false positive and false negative results in joint analyses of host and pathogen genomes.
    Front Genet, doi: 10.3389/fgene.2018.00266

Find out more about the Group’s activities



Jacques Fellay
Host-Pathogen Genomics Group
EPFL, Lausanne
Group Webpage

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Domain(s) of activity:

  • Genes and genomes
  • Human genetics
  • Immunology
  • Infectious diseases
  • Personalised medicine

Domain(s) of application:

  • Medicine and health