What we do

In the Host-Pathogen Genomics Group, we explore the genetic roots of inter-individual differences in response to infections, with a particular focus on the genomic interactions between pathogens and their human hosts. At the crossroads between basic science and the clinical world, we are committed to translational genomic research, aimed at identifying, validating and bringing to clinical use genetic markers of susceptibility to infectious diseases – e.g. host genomics of HIV infection, joint analyses of interactions between human and viral genomes, and exome sequencing on patients with extreme infectious disease phenotypes.

Find out more about the Group’s activities

Main publications 2020

  • Arora J et al.
    HLA Heterozygote Advantage against HIV-1 Is Driven by Quantitative and Qualitative Differences in HLA Allele-Specific Peptide Presentation
    Molecular Biology and Evolution, 10.1093/molbev/msz249
  • Thorball CW et al.
    Genetic variation near CXCL12 is associated with susceptibility to HIV-related non-Hodgkin lymphoma
    Haematologica, 10.3324/haematol.2020.247023
  • Zhang Q et al.
    Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
    Science, 10.1126/science.abd4570

Members

epfl

Jacques Fellay
Host-Pathogen Genomics Group
EPFL, Lausanne
Group Webpage

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Domain(s) of activity:

  • Genes and genomes
  • Human genetics
  • Immunology
  • Infectious diseases
  • Personalised medicine

Domain(s) of application:

  • Medicine and health

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