What we do

In the Host-Pathogen Genomics Group, we explore the genetic roots of inter-individual differences in response to infections, with a particular focus on the genomic interactions between pathogens and their human hosts. At the crossroads between basic science and the clinical world, we are committed to translational genomic research, aimed at identifying, validating and bringing to clinical use genetic markers of susceptibility to infectious diseases – e.g. host genomics of HIV infection, joint analyses of interactions between human and viral genomes, and exome sequencing on patients with extreme infectious disease phenotypes.

Main publications 2019

  • Arora J et al.
    HIV peptidome-wide association study reveals patient-specific epitope repertoires associated with HIV control
    PNAS, doi: 10.1073/pnas.1812548116
  • Chaturvedi N et al.
    Adaptation of hepatitis C virus to interferon lambda polymorphism across multiple viral genotypes
    eLife, doi: 10.7554/eLife.42542
  • Scepanovic P et al.
    A comprehensive assessment of demographic, environmental, and host genetic associations with gut microbiome diversity in healthy individuals
    Microbiome, doi: 10.1186/s40168-019-0747-x

Find out more about the Group’s activities

Members

epfl

Jacques Fellay
Host-Pathogen Genomics Group
EPFL, Lausanne
Group Webpage

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Domain(s) of activity:

  • Genes and genomes
  • Human genetics
  • Immunology
  • Infectious diseases
  • Personalised medicine

Domain(s) of application:

  • Medicine and health

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