What we do

We are Clinical Bioinformatics at the ETH Zurich core facility NEXUS Personalized Health Technologies. Our unit offers highly customizable bioinformatics and biostatistics services for projects in the field of biomedical research and development. We maintain close collaborations with hospitals in Switzerland, enabling and accelerating the use of top-notch data analysis, software development, and clinical decision support. Fee-for-service or joint collaboration, we aim for tailor-made full services for our clients, translating computational and analytical tools to meet their needs.

Find out more about the Group’s activities

Core facility activities

Here are some of the key services we provide (also see here):

  • Bioinformatics/biostatistical data analysis;
  • Translational research support;
  • Clinical decision support;
  • Software development.

Highlights 2019

The two major topics keeping CBU busy in 2019 were single-cell analyses and multi-omics diagnostics.
Triggered by the PHRT Tech Trans project together with the Genomics Facility Basel and the Computational Biology Group, both from the D-BSSE of ETH Zurich, we acquired several projects and trials dealing with single cells. Not only allowed this to establish a solid code base for the processing of such data, but also we have gained novel insights into experimental design using tools such as 10X and mission bio.
The goal to combine different data modalities such as genomics and clinical images to improve diagnostics in cancer and rare diseases is a hot topic globally. We have the privilege to participate in multiple such efforts in Switzerland and the EU. Blending bioinformatics pipelines with existing clinical annotations and adding some UX-driven frontend has caught the attention of an increasing number of medical institutions and researchers.
The Swiss Variant Interpretation Platform has moved from a concept to an actual system for testing the ideas of establishing a national reference for the interpretation of variants in cancer. The ongoing effort aims at establishing a production version 1.0 in June 2020.

Main Publications 2019

  • Shao W et al.
    Comparative analysis of mRNA and protein degradation in prostate tissues indicates high stability of proteins
    Nat Commun, doi: 10.1038/s41467-​019-10513-5
  • D’Amico L et al.
    A novel anti-​HER2 anthracycline-​based antibody-​drug conjugate induces adaptive anti-​tumor immunity and potentiates PD-​1 blockade in breast cancer
    Journal for ImmunoTherapy of Cancer, doi: 10.1186/s40425-​018-0464-1
  • Singer F et al.
    Commentary On SwissMTB: Establishing Comprehensive Molecular Cancer Diagnostics In Swiss Clinics
    J Cancer Treatment Diagn, doi: 10.29245/2578-2967/2019/1.1163

Members

University zurich

Daniel Stekhoven
Clinical Bioinformatics Unit
ETH Zurich
Group Webpage

Twitter button

Domain(s) of activity:

  • Core facility and competence centre
  • APIs
  • Biostatistics
  • Data visualisation
  • Drug resistance
  • Oncology
  • Personalised medicine
  • Proteomics
  • Single-cell biology
  • Software engineering
  • Transcriptomics

Domain(s) of application:

  • Basic research
  • Medicine and health

Tags