What we do

The Computational Biology Group (CoBi) develops computational models of developmental processes. We place a particular focus on mechanistic 4D image-based in silico models of organogenesis (mouse lung, kidney, pancreas, brain, Drosophila wing and eye) and on the delineation of fundamental mechanisms, such as those that restrict the size of organs and those that maintain the proportions of structures in different-sized embryos. The group runs a wet lab to obtain image data, and collaborates with tissue engineers to build spatially-organized tissue from stem cells, as well as with clinicians to apply its techniques to disease models.

Find out more about the Group’s activities

Main publications 2018

  • Boareto M et al.
    Positional information encoded in the dynamic differences between neighbouring oscillators during vertebrate segmentation.
    BioRxiv, https://doi.org/10.1101/286328
  • Menshykau D et al.
    Image-based modeling of kidney branching morphogenesis reveals GDNF-RET based turing-type mechanism and pattern-modulating WNT11 feedback.
    Nat Commun, https://doi.org/10.1038/s41467-018-08212-8

Members

University basel

Dagmar Iber
Computational Biology Group
ETH Zurich, D-BSSE, Basel
Group Webpage

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Domain(s) of activity:

  • Systems biology
  • Biophysics
  • Cell mechanobiology
  • Deep sequencing data
  • Evo-Devo
  • Experimental biology
  • Gene regulatory network analysis
  • In silico organogenesis
  • Mathematical modelling
  • Signaling pathways
  • Single-cell biology

Domain(s) of application:

  • Basic research
  • Medicine and health

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