What we do
The Computational Biology Group (CoBi) develops computational models of developmental processes. We place a particular focus on mechanistic 4D image-based in silico models of organogenesis (mouse lung, kidney, pancreas, brain, Drosophila wing and eye) and on the delineation of fundamental mechanisms, such as those that restrict the size of organs and those that maintain the proportions of structures in different-sized embryos. The group runs a wet lab to obtain image data, and collaborates with tissue engineers to build spatially-organized tissue from stem cells, as well as with clinicians to apply its techniques to disease models.
Find out more about the Group’s activities
Main publications 2019
- Menshykau D et al.
Image-based modeling of kidney branching morphogenesis reveals GDNF-RET based turing-type mechanism and pattern-modulating WNT11 feedback.
Nat Commun, https://doi.org/10.1038/s41467-018-08212-8 - Nikolaev Y et al.
Systems NMR: single-sample quantification of RNA, proteins and metabolites for biomolecular network analysis
Nat Methods, https://doi.org/10.1038/s41592-019-0495-7 - Zhang R et al.
Id4 Downstream of Notch2 Maintains Neural Stem Cell Quiescence in the Adult Hippocampus
Cell Reports, https://doi.org/10.1016/j.celrep.2019.07.014
