Luciano Cascione
Bioinformatics Core Unit
Institute of Oncology Research, Bellinzona
Group Webpage

What do we do?

Our main task at the Bioinformatics Core Unit (BCU) is to support the research groups at the Institute of Oncology Research (IOR) with computational and statistical services. Our research interests are focused on the genetics and biology of cancer with a major emphasis on lymphomas and epithelial cancers, such as prostate, breast and ovarian cancer. Importantly, more than as just a supporting role, we proactively identify and develop novel bioinformatics projects that can complement and in many cases drive our biologic research. In collaboration with the SIB Swiss Institute of Bioinformatics we develop innovative data analysis tools, visualization software and database resources for genomics research.

Highlights 2016

In 2016, the canton Ticino approved the integration of IOR into the new Faculty of Biomedical Sciences of the University of Lugano as of 2017. The new Faculty will offer a Masters degree in Medicine (3 years) starting in 2020, in close collaboration with, on the academic side, ETH Zurich, the University of Basel and the University of Zurich, and with the Ente Ospedaliero Cantonale and the private clinics in Ticino for the bedside teaching.

Main publications 2016

  • Akhmedov M et al. A divide and conquer matheuristic algorithm for the Prize-collecting Steiner Tree Problem . Computers & Operations Research 2016, 70, pp.18-25.
  • Vasquez R et al. The bromodomain inhibitor OTX015 (MK-8628) exerts anti-tumor activity in triple-negative breast cancer models as single agent and in combination with everolimus. Oncotarget. 2016 Dec 7.
  • Gaudio E et al. Combination of the MEK inhibitor pimasertib with BTK or PI3K-delta inhibitors is active in preclinical models of aggressive lymphomas. Annals of Oncology, 2016, 27(6), pp.1123-1128.

Our research topics: