What we do

The Computational Genetics and Epigenetics of Cancer Group aims to assess contribution of chromatin changes to cancer initiation and progression and associate them with genetic modifications. To achieve this goal, we employ advanced data analytics (in particular machine learning algorithms) and get biological insights, which we can further validate in the lab. The team is actively involved in creating novel accurate methods for studying genetic and epigenetic changes in cancer. Check the whole list of softwares developed by the team.

Find out about the Group’s activities

Main publications 2020

  • Kerdivel G and Boeva V
    Chromatin Immunoprecipitation Followed by Next-Generation Sequencing (ChIP-Seq) Analysis in Ewing Sarcoma
    Methods Mol Biol., 10.1007/978-1-0716-1020-6_21
  • Perez-Rathke A et al.
    CHROMATIX: computing the functional landscape of many-body chromatin interactions in transcriptionally active loci from deconvolved single cells
    Genome Biology, 10.1186/s13059-019-1904-z
  • Aynaud M-M et al.
    Transcriptional Programs Define Intratumoral Heterogeneity of Ewing Sarcoma at Single-Cell Resolution
    Cell Reports, 10.1016/j.celrep.2020.01.049

Members

eth zurich

Valentina Boeva
Computational Epigenetics of Cancer
ETH Zurich
Group Webpage

Domain(s) of activity:

  • Systems biology
  • Epigenetics
  • Gene regulatory network analysis
  • Gene regulation
  • Human genetics
  • Machine learning
  • Mathematical modelling
  • Next generation sequencing
  • Oncology
  • Personalised medicine
  • Signaling pathways

Domain(s) of application:

  • Medicine and health

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