A large international project, ENDOTARGET, aims to explore the causes of inflammation in arthritis. SIB has a crucial role in this endeavour by coordinating the data management, ensuring the quality and harmonization of datasets as well as by developing a tool supported by AI to predict which patients are likely to have more severe forms of the condition. This initiative, starting this month, has been awarded funding from the European Union and the Swiss State Secretariat for Education, Research and Innovation (SERI).
From gut microbiota to inflammation to arthritis
Chronic inflammation is a significant driver of diseases such as arthritis. In the case of rheumatoid arthritis, it leads to debilitating pain within the joints which can progress to severe levels, and even affect internal organs. While no cure currently exists for this disease, it is likely that conditions which prime the body to be in a more inflammatory state, such as systemic endotoxemia (see box), could be involved. ENDOTARGET, led by HUS Helsinki University Hospital, brings together SIB scientists with collaborators in Finland, Germany and Estonia. Data will be collected from several large patient cohorts to understand the role of systemic endotoxemia, gut microbiota and intestinal permeability in inflammatory diseases.