What we do
The individual cells of a body exhibit a stunning diversity of phenotypes, despite carrying a largely identical genetic makeup. This is due to the distinct ways in which the same genetic information can be read, interpreted and translated into function. At the RNA Regulatory Networks (RRN) Group at the Biozentrum in Basel, we combine computational modelling with big data and experimental analysis to discover and understand the regulatory networks governing the interpretation of genetic information at the level of tissues and single cells.
Find out more about the Group’s activities
Main publications 2019
- Herrmann CJ et al.
PolyASite 2.0: a consolidated atlas of polyadenylation sites from 3' end sequencing
Nucleic Acids Res, https://doi.org/10.1093/nar/gkz918 - Gruber AJ & Zavolan M
Alternative cleavage and polyadenylation in health and disease
Nat Rev Genet, https://doi.org/10.1038/s41576-019-0145-z - Riba A et al.
Protein synthesis rates and ribosome occupancies reveal determinants of translation elongation rates
PNAS, https://doi.org/10.1073/pnas.1817299116
