What we do
We study gene regulation through the analysis and modelling of genome-wide datasets. We collaborate closely with experimental researchers on various biological topics, including cancer progression, chromatin biology and cellular differentiation, using data from various aspects of gene expression, such as DNA methylation and RNA transcription in single cells, measured by high-throughput sequencing. Our aim is to better understand how the different layers of epigenetic, transcriptional and post-transcriptional regulation interact and contribute to the control of gene expression.
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Core facility activities
We help FMI scientists to exploit large data efficiently, depending on their specific needs, through collaboration, a bioinformatics helpdesk and relevant training. We focus on providing solutions based on free and open-source software, allowing the scientists to continue their own bioinformatics research even after leaving the FMI.
Here are some of the key services we provide (also see here):
- High-throughput data analysis, from experiment design to result interpretation;
- Training (one-on-one, lectures, workshops);
- Bioinformatics helpdesk;
- Software tool development.
Main publication 2021
- Iurlaro M et al.
Mammalian SWI/SNF continuously restores local accessibility to chromatin
Nat Genet, 10.1038/s41588-020-00768-w - Kitazawa T et al.
A unique bipartite Polycomb signature regulates stimulus-response transcription during development
Nat Genet, 10.1038/s41588-021-00789-z - Olivieri D et al.
Cooperation between HDAC3 and DAX1 mediates lineage restriction of embryonic stem cells
EMBO J, 10.15252/embj.2020106818
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