What we do

In the Proteome Informatics Group (PIG), we are involved in software and database development for the benefit of the proteomics and glycomics communities. These resources are made available through the ExPASy server. Software tools support experimental mass spectrometry data analysis, mainly for the detection of posttranslational modifications, with a strong focus on glycosylation. We also develop integrated tools and databases to query knowledge of carbohydrates attached to proteins, carbohydrate structures and protein-carbohydrate interactions.

The group develops the Glycomics@ExPASy portal.

Highlights 2018

In recent years, we have set out to collect and integrate information on carbohydrates/glycans whose role is increasingly described as key in many normal and pathological cellular processes. With the creation of a dedicated tab on the ExPASy server in 2015, we now centralise databases and tools that are useful for glycomics and glycoproteomics and gradually expand our range.
In 2018, in collaboration with CERMAV we introduced the UniLectin platform dedicated to lectins (protein receptors binding at least one carbohydrate, with no enzymatic function). The first release includes UniLectin3D a database that collects sequence, binding and 3D information upon which a lectin classification is proposed.
We also substantially increased the level of data and tool integration in GlyConnect, the main glycoproteomics resource in the Glycomics@ExPASy collection, mainly designed to support scientists in shaping assumptions on glycan-binding properties and glycan attachment on proteins.

Find out more about the Group’s activities

Main publications 2018

  • Mariethoz J et al.
    Glycomics@ExPASy: Bridging the gap
    Mol Cell Proteomics, doi: 10.1074/mcp.RA118.000799
  • Alocci D et al.
    Glyconnect: glycoproteomics goes visual, interactive and analytical.
    J Prot Res, doi: 10.1021/acs.jproteome.8b00766
  • Bonnardel F et al.
    UniLectin3D, a database of carbohydrate binding proteins with curated information on 3D structures and interacting ligands.
    Nucleic Acids Res, doi: 10.1093/nar/gky832

Members

University geneva

Frédérique Lisacek
Proteome Informatics Group
University of Geneva
Group Webpage

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Domain(s) of activity:

  • Proteins and proteomes
  • Database curation
  • Data visualisation
  • Glycomics
  • Protein interactions
  • Proteomics

Domain(s) of application:

  • Medicine and health

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