What we do

In the Proteome Informatics Group (PIG), we are involved in software and database development for the benefit of the proteomics and glycomics communities. These resources are made available through the Expasy server. Software tools support experimental mass spectrometry data analysis, mainly for the detection of posttranslational modifications, with a strong focus on glycosylation. We also develop integrated tools and databases to query knowledge of carbohydrates attached to proteins, carbohydrate structures and protein-carbohydrate interactions.

The group develops the Glycomics@Expasy portal.

Highlights 2020

  • The UniLectin platform now includes a lectin prediction component based on a newly proposed fold-based classification
  • Our visualisation toolbox was enriched with GlyConnect Compozitor that maps and compares glycomes as graphs of related glycan compositions
  • We released NRPro, an MS/MS analysis platform performing both automatic annotation and dereplication of Non-Ribosomal Peptides in support of the Norine database

Main publications 2020

  • Robin T et al.
    Examining and fine-tuning the selection of glycan compositions with GlyConnect Compozitor
    Mol Cell Proteomics, 10.1074/mcp.RA120.002041
  • Ricart E et al.
    Automatic Annotation and Dereplication of Tandem Mass Spectra of Peptidic Natural Products
    Anal Chem, 10.1021/acs.analchem.0c03208
  • Bonnardel F et al.
    LectomeXplore, an update of UniLectin for the discovery of carbohydrate-binding proteins based on a new lectin classification
    Nucleic Acids Res, 10.1093/nar/gkaa1019