What we do

In the Evolutionary Systems Biology Group, we study the evolution and evolvability of biological systems at all levels of biological organization, from genes and genomes to biological networks and whole organisms. We develop bioinformatics tools to integrate data from a variety of sources, including comparative whole-genome sequence data, microarray expression data, and high-throughput protein interaction data. Our work uses comparative analysis of genomic data, laboratory evolution experiments and mathematical modelling.

Main publications 2018

  • Schaerli Y et al.
    Synthetic circuits reveal how mechanisms of gene regulatory networks constrain evolution.
    Mol Syst Biol, doi: 10.15252/msb.20178102
  • Hosseini S R and Wagner A
    Genomic organization underlying deletional robustness in bacterial metabolic systems.
    PNAS, doi: 10.1073/pnas.1717243115
  • Sprouffsky K et al.
    High mutation rates limit evolutionary adaptation in Escherichia coli.
    PLoS Genet, doi: 10.1371/journal.pgen.1007324

Find out more about the Group’s activities


University zurich

Andreas Wagner
Evolutionary Systems Biology Group
University of Zurich
Group Webpage

Domains of activity:

  • Evolution and phylogeny
  • Comparative genomics
  • Deep sequencing data
  • Experimental biology
  • Gene regulatory network analysis
  • Population genetics
  • Systems biology

Domain of application:

  • Basic research