What we do
In the Evolutionary Systems Biology Group, we study the evolution and evolvability of biological systems at all levels of biological organization, from genes and genomes to biological networks and whole organisms. We develop bioinformatics tools to integrate data from a variety of sources, including comparative whole-genome sequence data, microarray expression data, and high-throughput protein interaction data. Our work uses comparative analysis of genomic data, laboratory evolution experiments and mathematical modelling.
Find out about the Group’s activities
Main publications 2020
- Zheng J et al.
Selection enhances protein evolvability by increasing mutational robustness and foldability
Science, 10.1126/science.abb5962 - Dasmeh P and Wagner A
Natural Selection on the Phase-Separation Properties of FUS during 160 My of Mammalian Evolution
Molecular Biology and Evolution, 10.1093/molbev/msaa258 - Schweizer G and Wagner A
Genotype networks of 80 quantitative Arabidopsis thaliana phenotypes reveal phenotypic evolvability despite pervasive epistasis
PLOS Computational Biology, 10.1371/journal.pcbi.1008082
