What we do

In the Evolutionary Systems Biology Group, we study the evolution and evolvability of biological systems at all levels of biological organization, from genes and genomes to biological networks and whole organisms. We develop bioinformatics tools to integrate data from a variety of sources, including comparative whole-genome sequence data, microarray expression data, and high-throughput protein interaction data. Our work uses comparative analysis of genomic data, laboratory evolution experiments and mathematical modelling.

Find out about the Group’s activities

Main publications 2020

  • Zheng J et al.
    Selection enhances protein evolvability by increasing mutational robustness and foldability
    Science, 10.1126/science.abb5962
  • Dasmeh P and Wagner A
    Natural Selection on the Phase-Separation Properties of FUS during 160 My of Mammalian Evolution
    Molecular Biology and Evolution, 10.1093/molbev/msaa258
  • Schweizer G and Wagner A
    Genotype networks of 80 quantitative Arabidopsis thaliana phenotypes reveal phenotypic evolvability despite pervasive epistasis
    PLOS Computational Biology, 10.1371/journal.pcbi.1008082


University zurich

Andreas Wagner
Evolutionary Systems Biology Group
University of Zurich
Group Webpage

Domain(s) of activity:

  • Evolution and phylogeny
  • Systems biology
  • Comparative genomics
  • Deep sequencing data
  • Experimental biology
  • Gene regulatory network analysis
  • Population genetics

Domain(s) of application:

  • Basic research