What we do

In the Bioinformatics Core Facility (BCF), we promote trans-disciplinary collaborations between research teams in medicine, molecular biology, genetics, genomics, statistics, and bioinformatics. In particular, we carry out analyses of biomedical-genomics data with a focus on biomarker studies in cancer research, building on our specific expertise in statistical methods for genomics data analysis. Recently, we have concentrated on molecular heterogeneity in cancer, colorectal cancer, single cells transcriptomics, genetic association studies, metagenomics and other new technologies. We are open to any kind of new research direction.

Find out about the Group’s activities

Core facility activities

Biostatistics and Bioinformatics, in particular for:

  • Experimental, translational and clinical oncology
  • Single cell RNAseq, CyTOF and similar
  • Analysis of any "SEQ" or profiling study data
  • Genetics, epidemiology and patient data
  • New methods

Main publications 2020

  • Germann M et al.
    Neutrophils suppress tumor-infiltrating T cells in colon cancer via matrix metalloproteinase-mediated activation of TGFbeta.
    EMBO Molecular Medicine, 10.15252/emmm.201910681
  • Jacob L et al.
    Controlling technical variation amongst 6693 patient microarrays of the randomized MINDACT trial
    Communications Biology, 10.1038/s42003-020-1111-1
  • Ragusa S et al.
    Antiangiogenic immunotherapy suppresses desmoplastic and chemoresistant intestinal tumors in mice
    Journal of Clinical Investigation, 10.1172/JCI129558

Find out more about the Group’s activities

Members

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Mauro Delorenzi & Frédéric Schütz
Bioinformatics Core Facility (BCF)
University of Lausanne
Group Webpage

Domain(s) of activity:

  • Core facility and competence centre
  • Biomarkers
  • Data mining
  • Deep sequencing data
  • Mathematical modelling
  • Metagenomics
  • Next generation sequencing
  • Oncology
  • Single-cell biology
  • Transcriptomics

Domain(s) of application:

  • Basic research
  • Medicine and health

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