Mauro Delorenzi & Frédéric Schütz's group

What we do

In the Bioinformatics Core Facility (BCF), we promote trans-disciplinary collaborations between research teams in medicine, molecular biology, genetics, genomics, statistics, and bioinformatics. In particular, we carry out analyses of biomedical-genomics data with a focus on biomarker studies in cancer research, building on our specific expertise in statistical methods for genomics data analysis. Recently, we have concentrated on molecular heterogeneity in cancer, colorectal cancer, single cells transcriptomics, genetic association studies, metagenomics and other new technologies. We are open to any kind of new research direction.

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Core facility activities

Biostatistics and Bioinformatics, in particular for:

• Experimental, translational and clinical oncology
• Single cell RNAseq, CyTOF and similar
• Analysis of any "SEQ" or profiling study data
• Genetics, epidemiology and patient data
• New methods

Main publications 2020

• Germann M et al.
  Neutrophils suppress tumor-infiltrating T cells in colon cancer via matrix metalloproteinase-mediated activation of TGFbeta.
  EMBO Molecular Medicine, 10.15252/emmm.201910681
• Jacob L et al.
  Controlling technical variation amongst 6693 patient microarrays of the randomized MINDACT trial
  Communications Biology, 10.1038/s42003-020-1111-1
• Ragusa S et al.
  Antiangiogenic immunotherapy suppresses desmoplastic and chemoresistant intestinal tumors in mice
  Journal of Clinical Investigation, 10.1172/JCI129558

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Members