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Frédérique Lisacek
Proteome Informatics Group
University of Geneva
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What do we do?

In the Proteome Informatics Group (PIG), we are involved in software and database development for the benefit of the proteomics and glycomics communities. These resources are made available through the ExPASy server. Software tools support experimental mass spectrometry data analysis, mainly for the detection of posttranslational modifications, with a strong focus on glycosylation. We also develop integrated tools and databases to query knowledge of carbohydrates attached to proteins, carbohydrate structures and protein-carbohydrate interactions.

Highlights 2017

In recent years, we have set out to collect and integrate information on carbohydrates/glycans, whose role is increasingly described as key in many normal and pathological cellular processes. With the creation of a dedicated tab on the ExPASy server in 2015, we now centralize databases and tools that are useful for glycomics and glycoproteomics and are gradually expanding our range. In 2017, we introduced three new tools:
  • Glynsight, a web interface to upload, visualize and interactively compare glycan expression profiles;
  • EpitopeXtractor, a tool that extracts glycan determinants (binding motifs) from a list of glycan structures and maps their shared features;
  • Glyconnect, a platform integrating several sources of information to characterize the molecular actors of glycosylation, mainly glycoproteins and N- and O-linked glycans.

Main publications 2017

  • Horlacher O et al. Glycoforest 1.0 Anal Chem. 2017; 89(20):10932
  • Domagalski et al. PepSweetener: a web-based tool to support manual annotation of intact glycopeptide MS spectra, in press Proteomics- Clinical applications
  • Campbell et al. Chapter 52: Glycoinformatics. Essentials of Glycobiology, 3rd edition, 2017; pp667-679. Cold Spring Harbor (NY)

Our main research topic: