What we do

We develop and apply computational and – most recently – experimental methods to analyse and design complex cellular networks, with a focus on large-scale mechanistic approaches. The group comprises biologists, computer scientists, engineers, and mathematicians, who perform interdisciplinary research in systems and synthetic biology. We focus on developing and applying computational methods and mechanistic mathematical models to study complex cellular networks and their operating principles, and to enable their rational re-design. Applications rely on our experimental lab, which uses budding yeast as a model organism, and on collaboration.

Main publications 2018

  • Yordanov P and Stelling J
    Steady-state differential dose response in biological systems.
    Biophys J, doi: 10.1016/j.bpj.2017.11.3780
  • Whitehead E et al.
    Automated planning enables complex protocols on liquid-handling robots.
    ACS Synt Biol, doi: 10.1021/acssynbio.8b00021
  • Widmer LA and Stelling J
    Bridging intracellular scales by mechanistic computational models.
    Curr Opin Biotechnol, doi: 10.1016/j.copbio.2018.02.005

Find out more about the Group’s activities


University basel

Joerg Stelling
Computational Systems Biology Group
D-BSSE, ETH Zurich, Basel
Group Webpage

Domains of activity:

  • Systems biology
  • Mathematical modelling
  • Signaling pathways
  • Single-cell biology
  • Synthetic biology

Domain of application:

  • Basic research
  • Medicine and health