“This was the work of a fantastic team of students and post-docs from our labs, that have brought together multiple computational and experimental expertise over the past years,” says Ciriello.

The team discovered that a mutation of a particular gene led to entire chromatin domains being affected, changing 3D interactions and expression of tumour-suppressive genes within these domains.

The study is published in the journal Nature Genetics.

Read the full EPFL press release

Donaldson-Collier M. C. et al. EZH2 oncogenic mutations drive epigenetic, transcriptional, and structural changes within chromatin domains. Nature Genetics 2019. DOI: 10.1038/s41588-018-0338-y

Illustration: Chromatin contacts in the cell nucleus that activate transcription Credit: Giovanni Ciriello