Deep learning: a leap forward for protein structure prediction

What do moving a muscle, reading this article, hearing music and digesting our food have in common? All important functions of life are performed by proteins, and their characteristic 3-dimensional structures determine their ability to perform these diverse tasks. This is why generations of structural biologists have been restlessly trying to crack the protein-folding nut, with more or less success. This week, several deep learning methods have led to remarkable advances at the global event for the evaluation of protein structure prediction methods: the 13th CASP experiment. Torsten Schwede and Matteo Dal Peraro, two SIB Group Leaders involved on the organizational and evaluation side of CASP13, tell us more.

November Virtual Seminar by Joshua L. Payne: an interview

The hills and valleys of evolution
During the course of the 20th Century, the American population geneticist Sewall Wright was the first to depict evolution as landscapes...

Switzerland: a good place to be to study ancient bones

The genomic history of the Americas’ peopling was recently uncovered from ancient DNA by a team of over 50 researchers, with SIB Group Leader Anna-Sapfo Malaspinas at the University of Lausanne co-leading the bioinformatics analyses.

November publications

Take a tour of SIB members' latest peer-reviewed articles and conference proceedings

Zooming into our metabolism

Every minute, each one of our trillions of cells carries out countless chemical reactions to convert food into energy, build proteins and eliminate toxic waste for instance. Taken as a whole, all these reactions make up our metabolism. But by which underlying mechanisms is it regulated?

Latest Protein Spotlight: On mar and motion

Movement is what sustains life. Organisms need to move to find food, seek shelter and to reproduce. Mobility is also essential inside organisms where cells are continuously dividing and migrating. There is also unceasing movement inside every cell where myriads of molecules are being trafficked, and cellular compartments of all shapes and sizes shifted. What keeps things moving?

Increasing the impact of SIB’s bioinformatics resources

What does it imply to increase the impact of a bioinformatics resource when its scientific relevance is already established and recognized? Since February 2018, a dedicated SIB team has been working hand-in-hand with resource developers to create a best-practice toolkit that will help them to grow their user base and share their know-how with the community.

Precision medicine and the role of bioinformatics: four short films to understand

Bioinformatics is fundamental to precision medicine. But why? How do hospitals and researchers benefit from bioinformatics to help patients? Canal9 TV Channel, the Oncology department of UNIL/CHUV and SIB all set out together to find answers to these exact questions.

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