La bioinformatique est devenue indispensable pour convertir les questions biologiques en réponses. Découvrez l'étendue des travaux et des contributions de nos scientifiques à travers leurs publications.

Source : Europe PMC, dernière mise à jour : 01.02.26

Découvrez les Remarkable Outputs 2024 du SIB

Les Remarkable Outputs sont sélectionnés par le comité du prix afin de présenter à la communauté les réalisations annuelles des scientifiques du SIB qui méritent particulièrement d'être soulignées. Des nouveaux algorithmes permettant de détecter les gènes liés à des maladies à l'exploration des origines de la reproduction sexuée, découvrez cette liste restreinte de publications, d'outils logiciels, de bases de données et de projets de vulgarisation.

Articles évalués par des pairs et prépublications

  1. Barua A, Srivastava M, Beinsteiner B, Laudet V, Robinson-Rechavi M. Estimates of molecular convergence reveal multiple genes with adaptive variation across teleost fish. Mol Biol Evol 2026;43(1):msag015
  2. Bejarano L, Hernández-Barranco A, Roh V, Méndez RS, Lamprou E, Costa CF, Ballabio M, Hegi ME, Fournier N, Joyce JA. Tumor-derived aminopeptidase N promotes early stages of brain metastatic colonization. Cell Rep 2026;45(2):116895
  3. Bozzi D, Broomandkhoshbacht NZ, Delgado M, Buikstra JE, Amorim CEG, Kassadjikova K, Estrada MP, Greub G, Rascovan N, Šmajs D, Fehren-Schmitz L, Malaspinas AS, Nelson EA. A 5500-year-old <i>Treponema pallidum</i> genome from Sabana de Bogotá, Colombia. Science 2026;391(6783):eadw3020
  4. Cina A, Monzon M, Galbusera F, Jutzeler CR. Quantifying central canal stenosis prediction uncertainty in SpineNet with conformal prediction. Sci Rep 2026
  5. Crowell HL, Llaó-Cid L, Frigola G, Gunz S, Ruano I, Lorden P, Ruiz M, Kulis M, Martin-Subero JI, Heyn H, Campo E, Pascual-Reguant A. A Transcriptional Map of Human Tonsil Architecture: Beyond the Sum of (Single Cell) Parts. Eur J Immunol 2026;56(1):e70121
  6. Duroux D, Melograna F, Climente-González H, Fan B, Walakira A, Gervasoni EE, Li Z, Roqueiro D, Stella F, Van Steen K. Turning heterogeneity of statistical epistasis networks to an advantage. Brief Bioinform 2026;27(1):bbaf699
  7. Duroux D, Meyer PP, Visoná G, Beerenwinkel N. Generalizable machine learning models for rapid antimicrobial resistance prediction in unseen healthcare settings. Gigascience 2026:giaf156
  8. Giagiozis M, Curt A, Jutzeler CR, Zariffa J. Video summarization for home-based egocentric footage in spinal cord injury rehabilitation. Biomed Eng Online 2026
  9. Grover A, Muser T, Kasak L, Zhang L, Krymova E, Boeva V. Early feature extraction drives model performance in high-resolution chromatin accessibility prediction. Genome Res 2026:gr.281042.125
  10. Haemmerli P, Hubert M, Gaudry A, Quiros-Guerrero LM, Mehl F, Pagni M, Marcourt L, Kirchhoffer OA, Grondin A, Constant S, Huang S, Queiroz EF, Clément S, Tapparel C, Wolfender JL. An innovative approach for anti-respiratory syncytial virus compound discovery from plant extracts, combining high-throughput screening and metabolomics. Biomed Pharmacother 2026;194:118917
  11. Hernández-Plaza A, Deng Z, Robledo-Yagüe F, Szklarczyk D, von Mering C, Bork P, Huerta-Cepas J. eggNOG v7: phylogeny-based orthology predictions and functional annotations. Nucleic Acids Res 2026;54(d1):D402-D408
  12. Huang Q, Szklarczyk D, Oehninger J, von Mering C. PaxDb v6.0: reprocessed, LLM-selected, curated protein abundance data across organisms. Nucleic Acids Res 2026;54(d1):D427-D439
  13. Jauch AJ, Schmidt-Barbo P, Schultheiss C, Silling G, Hänel M, Chromik J, Stauch T, Trautmann-Grill K, Repp R, Schulte C, Fleischmann B, Welslau M, Stauch M, Quiering C, Richter F, Tesanovic T, Jahn S, Bignucolo O, Holbro A, Passweg JR, Matzdorff A, Rummel M, Meyer O, Nimmerjahn F, Binder M. Efficacy and safety of eltrombopag in combination with dexamethasone as first-line treatment in adult patients with newly diagnosed immune thrombocytopenia for the British Journal of Haematology. Br J Haematol 2026
  14. Killer HE, Pircher A, Stekhoven DJ. Reassessment of the Collaborative Normal-Tension Glaucoma Study: Statistical Evidence and Implications for Current Management. Ophthalmol Ther 2026
  15. Kondrateva O, Sonay TB, Zlobec I, Anisimova M. Tumor mutational burden predicts neoantigen profiles and immunotherapy response in microsatellite stable tumors across different cancer types. Front Immunol 2025;16:1582464
  16. Kossmann D, Iizuka A, Khanna N, Rivera-Fuentes P. A Ratiometric pH Sensor for Gram-Positive and Gram-Negative Bacteria. J Am Chem Soc 2026
  17. Lawless D, Saadat A, Oumelloul MA, Boutry S, Stadler V, Österle S, Armida J, Haerry D, Froese DS, Schlapbach LJ, Fellay J. Application of qualifying variants for genomic analysis. Bioinformatics 2026:btaf676
  18. Lepik K, Auwerx C, Sadler MC, van der Graaf A, Ojavee SE, Kutalik Z. LiMA: Robust inference of molecular mediation from summary statistics. Am J Hum Genet 2026;113(1):202-220
  19. Malfertheiner L, Tackmann J, Matias Rodrigues JF, von Mering C. Community conservatism is widespread across microbial phyla and environments. Nat Ecol Evol 2026
  20. Morales-Tirado A, Blitz-Castro E, Tabares-González A, Gascón-Galindo C, Vicente-Santamaría S, Luna-Paredes C, Salcedo-Lobato E, Boutry S, Lamas-Ferreiro A. Long-term Outcomes of Pediatric CFSPID: A 15-Year Clinical and Genomic Study Across Newborn Screening Cystic Fibrosis Units. Arch Bronconeumol2026:S0300-2896(26)00006-2
  21. Moretti S, Niknejad A, Pagni M, Mehl F. MetaNetX: a bridge between metabolic resources for enhanced curation and multi-omics data harmonization. Nucleic Acids Res 2026;54(d1):D617-D622
  22. Mulberry N, Stadler T. Strategies for resolving cellular phylogenies from sequential lineage tracing data. Theor Popul Biol 2026;168:32-43
  23. Munteanu V, Saldana MA, Dreifuss D, Ouyang WO, Ferdous J, Mohebbi F, Roseberry JS, Ciorba D, Bostan V, Gordeev V, Drabcinski N, Su JM, Kasianchuk N, Sharma NK, Knyazev S, Aßmann E, Lobiuc A, Covasa M, Crandall KA, Wu NC, Mason CE, Tierney BT, Lucaci AG, Ophoff RA, Gibas C, Rzymski P, Skums P, Solo-Gabriele H, Niko B, Zelikovsky A, Hölzer M, Smith A, Mangul S. SARS-CoV-2 wastewater genomic surveillance: approaches, challenges, and opportunities. Genome Biol 2026;27(1):1
  24. Pecnik J, Ventresca Miller AR, Panse C, Kunz L, Dittmann A, Johnson JA, Makhortykh S, Litvinova L, Andrukh S, Toschev G, Krützen M, Schuenemann VJ, Wilkin S. Paleo-proteomic analysis of Iron Age dental calculus provides direct evidence of Scythian reliance on ruminant dairy. PLoS One 2026;21(1):e0339464
  25. Perez MAS, Zoete V. Universal paratope-epitope interaction patterns in antibody-antigen structures. Protein Sci 2026;35(1):e70401
  26. Prélot L, Chen J, Hüser M, Kahles A, Rätsch G. ImmunoPepper: extracting personalized peptides from complex splicing graphs. Bioinformatics 2026;42(1):btaf492
  27. Pu T, Peddle AM, Wirapati P, Tsantoulis P, Wu Q, Hong Y, Samuel L, Desai J, Riener M, Saridaki Z, Cunningham D, Tejpar S. Exploratory biomarker analysis of RAS/BRAF somatic mutations and gene expression signatures for predicting treatment effects of aflibercept in the velour trial. NPJ Precis Oncol 2026
  28. Rutz A, Probst D, Aguilar C, Akiyama DY, Alberti F, Augustijn HE, Avalon NE, Beemelmanns C, Barbieri HB, Biermann F, Bridge AJ, Girón EC, Cox R, Crüsemann M, D'Agostino PM, Feuermann M, Gerke J, García KG, Holme JE, Hwang JY, Iacovelli R, Jeronimo Barbosa JC, Kaur N, Klapper M, Köhler AM, Korenskaia A, Kubach N, Lee BT, Loureiro C, Mantri S, Narula S, Meijer D, Navarro-Muñoz JC, Nguyen GS, Paliyal S, Panghal M, Rao L, Sieber S, Sokolova N, Sowa ST, Szenei J, Terlouw BR, Weddeling HG, Yu J, Ziemert N, Weber T, Blin K, van der Hooft JJJ, Medema MH, Zdouc MM. MITE: the Minimum Information about a Tailoring Enzyme database for capturing specialized metabolite biosynthesis. Nucleic Acids Res 2026;54(d1):D635-D642
  29. Shapiro I, Kräuchi C, Luca E, Dettwiler S, Peitzsch M, Qi W, Reul A, Beuschlein F, Maccio U, Nölting S, Debaix H, Hantel C. A novel 2D and 3D model for primary adrenocortical carcinoma of advanced and metastasized stage co-secreting cortisol, aldosterone, testosterone and 18-oxo/18OH-cortisols. Endocr Relat Cancer2026:ERC-25-0385
  30. Sigrist CJA, Cuche BA, de Castro E, Coudert E, Redaschi N, Bridge A. The PROSITE database for protein families, domains, and sites. Nucleic Acids Res 2026;54(d1):D451-D458
  31. Tauriello G, Lill Y, Sgrignani J, Zoete V, Singer B, Vallat B, Webb BM, Garello T, Bienert S, Feig M, Papaleo E, Burley SK, Sali A, Lill MA, Cavalli A, Peraro MD, Schwede T. ModelCIF update: Supporting Emerging Classes of Computational Macromolecular Models. J Mol Biol 2026:169658
  32. Vallois D, Missiaglia E, Veloza L, Fischer A, Cavalieri D, Rattina V, Bisig B, Roh V, Wiehle L, Sarkis R, Bachy E, Bonnet C, Bruneau J, Cairoli A, De Wind R, Drieux F, Dubois R, Emile JF, Fataccioli V, Laribi K, Ledoux-Pilon A, Lemonnier F, Llamas-Gutierrez F, Morel P, Parrens M, Poullot E, Quintanilla-Martinez L, Sandrini J, Somja J, Xerri L, Tournilhac O, Gaulard P, Siebert R, de Leval L. Correction: Divergent molecular pathways drive monomorphic epitheliotropic and enteropathy-associated intestinal T-cell lymphoma. Leukemia 2026;40(1):252-259
  33. Varliero G, Bauder A, Stierli B, Qi W, Frey B. Erratum: Host-virome associations in the weathering crust of a rapidly retreating temperate Alpine glacier. Microb Genom 2026;12(1)
  34. Vessman B, Guridi-Fernández P, Arias-Sánchez FI, Mitri S. Novel artificial selection method improves function of simulated microbial communities. PLoS Comput Biol 2026;22(1):e1013863
  35. Yang Z, Baudis M. CNAttention: an attention-based deep multiple-instance method for uncovering copy number aberration signatures across cancers. Brief Bioinform 2026;27(1):bbaf696

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