At the Swiss-Prot Group we develop, annotate and maintain the UniProtKB/Swiss-Prot protein sequence database, the most widely used protein information resource in the world. We also develop and maintain other databases including PROSITE, a database of protein families and domains, ENZYME, a database of enzyme nomenclature, HAMAP , a collection of manually curated family profiles for protein classification, and associated, manually created annotation rules, RHEA, a curated database of chemical reactions and SwissLipids, an expert-curated resource that integrates lipidomics data with biological knowledge. We also offer to the virologists community the ViralZone portal. The group also co-heads the development and maintenance of the ExPASy proteomics website. We are one of the largest groups in the Swiss Institute of Bioinformatics.