It has been obvious for quite some time that studying only gene (DNA) sequences is insufficient to give a complete description of the proteins they encode. As part of the lifescience community is focusing on studying proteins the needs for a comprehensive resource that gathers bona fide information about proteins, their function, post-translation modifications, interactions, or their location in cells and organisms is ever more important. Our group is dedicated to the creation and maintenance of several protein databases, as well as to make our most used and valued resource (the UniProtKB/Swiss-Prot knowledgebase prepared in collaboration with the UniProt team of EBI)  evolve with the users' needs.


One of the major strengths of our group is its annotation capacity served by expert staff scientists and supported by a dedicated team of software developers and bioinformaticians.
We offer services in:

  • Annotation: we focus our efforts on the following protein families: Chordata, plant, prokaryotic, viral, fungal, animal
  • Enhancement and automation (e.g. PROSITE)
  • Software development
  • Communication for the public at large and the scientific community in the field of protein biology: The group produces Protein Spotlight, a periodic review on proteins, and maintains a server Protéines à la Une providing basic information on the world of proteins in French.


  • UniProtKB/Swiss-Prot
    The Swiss-Prot Group develops and maintains the UniProtKB/Swiss-Prot database. This task is performed in collaboration with the European Bioinformatics Institute (EBI) in Hinxton (UK) and the Protein Information Resource (PIR) in Georgetown (USA). UniProtKB/Swiss-Prot is the most widely used protein information resource in the world, with over 900,000 visits per month. It provides concise, but thorough, descriptions of a non-redundant set of over 547,000 proteins including their function, domain structure, post-translational modifications and variants. Its high-quality annotation is the fruit of manual expert curation by biologists, who use information available in the scientific literature to provide an accurate description of each protein’s features.
    The Swiss-Prot Group develops and maintains other databases, including PROSITE, a database of protein families and domains.
    The Swiss-Prot Group develops and maintains ENZYME, a database of enzyme nomenclature.
    The HAMAP is a collection of manually curated family profiles for protein classification, and associated, manually created annotation rules
  • ExPASy
    The ExPASy website, set up in 1993, was the first Internet portal in the life sciences. The portal is an entry point to several databases, including those developed by the different SIB groups, and to various online bioinformatics tools. The Swiss-Prot Group participates in maintaining and further developing the ExPASy websites together with the SIB Web Team.
  • ViralZone
    The ViralZone website is dedicated to the virologists community and offers a thorough description of the viral world and links to UniProtKB/Swiss-Prot.
  • RHEA
    RHEA is a freely available, manually annotated database of chemical reactions. It is the result of a collaborative project between the SIB Swiss-Prot Group and the Chemoinformatics and Metabolism Group at EBI.
  • SwissLipids
    SwissLipids is an expert curated resource that provides a framework for the integration of lipid and lipidomic data with biological knowledge and models.