sciCORE is a centre of competence in scientific computing. It provides high-performance computing infrastructure, large-scale storage resources, scientific software and databases, server infrastructures and user support as well as know-how and expertise to scientific research groups. At sciCORE we provide a professional environment for scientific applications: from bioinformatics, computational chemistry, physics and systems biology to medicine and economics. In direct collaboration with scientific research groups, we help develop, deploy, operate and extend the computational tools required for performing modern life science and biomedical research. We operate the IT infrastructure for several SIB services, e.g. SWISS-MODEL and SwissRegulon.