Torsten Schwede
Computational Structural Biology Group
University of Basel
Group Webpage

What do we do?

In the Computational Structural Biology (CSB) Group, we focus on the development of methods and algorithms to model, simulate and analyse three-dimensional protein structures and their molecular properties in order to apply these techniques to the understanding of biological processes at a molecular level. Our main emphasis is on homology modelling – using evolutionary information to model protein tertiary and quaternary structures. Applications in biomedical research include the study of protein-ligand interactions, drug discovery, structure-guided protein engineering, and the interpretation of disease-causing mutations.

Main publications 2017

  • Bertoni M et al. Modeling protein quaternary structure of homo- and hetero-oligomers beyond binary interactions by homology. Sci Rep. 2017; 7: 10480.
  • Bienert  S et al. The SWISS-MODEL Repository - new features and functionality. Nucleic Acids Res. 2017; 45:D313-D319.
  • Haas  J et al. Continuous Automated Model Evaluation (CAMEO) Complementing the Critical Assessment of Structure Prediction in CASP12. Proteins, [Epub ahead of print].

Our main research topic: