What do we do?
In the Computational Structural Biology (CSB) Group, we focus on the development of methods and algorithms to model, simulate and analyse three-dimensional protein structures and their molecular properties in order to apply these techniques to the understanding of biological processes at a molecular level. Our main emphasis is on homology modelling – using evolutionary information to model protein tertiary and quaternary structures. Applications in biomedical research include the study of protein-ligand interactions, drug discovery, structure-guided protein engineering, and the interpretation of disease-causing mutations.
Main publications 2017
- Bertoni M et al. Modeling protein quaternary structure of homo- and hetero-oligomers beyond binary interactions by homology. Sci Rep. 2017; 7: 10480.
- Bienert S et al. The SWISS-MODEL Repository - new features and functionality. Nucleic Acids Res. 2017; 45:D313-D319.
- Haas J et al. Continuous Automated Model Evaluation (CAMEO) Complementing the Critical Assessment of Structure Prediction in CASP12. Proteins, [Epub ahead of print].