What do we do?
In the Evolutionary Bioinformatics Group, we are mainly concerned with determining the role of evolutionary innovation and constraint in animals. For this, we develop methods and databases to extract reliable information from genome and transcriptome data. These include Bgee, a database for gene expression evolution, and Selectome, a database of positive selection. While developing these resources, we also conduct research on ontologies, biocuration, and high-performance computing. Our biological focus is to link Evo-Devo with phylogenomics. Notably, we study the role of gene duplication in the divergence between genes and between species.
Bgee has increased from 17 to 29 species, and integrates a fully curated subset of healthy GTEx data. The group is partner to two of the projects selected in the PNR "Big Data".
Main publications 2017
- Roux J et al. Selective constraints on coding sequences of nervous system genes are a major determinant of duplicate gene retention in vertebrates. Mol. Biol. Evol. 2017; 34:2773–2791
- Daub JT et al. Detection of Pathways Affected by Positive Selection in Primate Lineages Ancestral to Humans. Mol. Biol. Evol. 2017; 34:1391-1402.
- Maitre D et al. Sex differentiation in grayling (Salmonidae) goes through an all-male stage and is delayed in genetic males who instead grow faster. Scientific Reports. 2017; 7:15024