What do we do?
We develop and apply statistical methodologies to large human phenotype-genotype datasets, to address long-standing questions in population and quantitative genetics. These have improved the prediction accuracy of disease risk in personalized medicine, quantified the contribution of genotype-environment interaction effects to obesity risk, and provided frameworks to examine the genetic basis of phenotypic differences among people. Our current work focuses on improved testing for sex-, age-, or environment-specific genetic effects and investigating the role of interactions between microbial and host genotypes in shaping human phenotypes.
Main publications 2017
- Robinson MR et al. Genotype–covariate interaction effects and the heritability of adult body mass index. Nat Genet. 2017
- Robinson MR et al. Genetic evidence of assortative mating in humans. Nat Hum Behav. 2017
- Tropf C et al. Hidden heritability due to heterogeneity across seven populations. Nat Hum Behav. 2017