What do we do?
Systems biology is aimed at a quantitative and dynamic understanding of cellular networks by combining experimental data with theoretical and computational methodologies. Our interest lies in the regulatory and cellular networks involved in oncogenic signalling, cell-cycle regulation, and molecular oscillators. Data obtained from technologies such as microarrays, chromatin-immunoprecipitation (ChIP) and genome sequencing are brought together to discover regulatory dependencies between genes and regulatory proteins involved in cell proliferation. One thematic focus is the study of biomolecular oscillators, in particular the circadian clock.
Main publications 2017
- Yeung J et al. Transcription factor activity rhythms and tissue-specific chromatin interactions explain circadian gene expression across organs. Genome Res., 2017
- Mauvoisin D et al. Circadian and Feeding Rhythms Orchestrate the Diurnal Liver Acetylome. Cell Rep. 2017; 20(7), p. 1729-1743.
- Sobel JA et al. Transcriptional regulatory logic of the diurnal cycle in the mouse liver. PLoS Biol. 2017, 15(4), p. e2001069.