Computational Cancer Biology

In the Computational Cancer Biology Group, our aim is to study interactions between cancer and immune cells. We are focusing on molecular and cellular aspects of cancer immune cell interactions. At the molecular level, we have developed tools to predict (neo-)antigen presentation from HLA peptidomics datasets and are currently working on TCR-peptide-HLA interaction predictions. At the cellular level, we are developing novel approaches to characterizing immune infiltrations and the different states of immune cells from (single-cell) gene expression data.