Laurent Falquet
Bioinformatics Unravelling Group (BUGFri)
University of Fribourg
Group Webpage

What do we do?

In the Bioinformatics Unravelling Group of the University of Fribourg (BUGFri), we support life science researchers by providing expertise in data analysis of Next-Generation Sequencing (NGS) experiments, or any large-scale biological experiment requiring bioinformatics resources. We focus on genome assembly, annotation and comparison, as well as on mutant and structure variant identification by resequencing. We also perform metagenomics, RNAseq and ChIPseq data analysis, proteome clustering and ortholog/paralog classification, as well as pathway and gene set enrichment analysis.

Highlights 2017

In 2017, the Sinergia project "Pangenomic and comprehensive analysis of the relationship between bacterial toxin-antitoxin systems and antibiotic phenotype" continued. We are now working towards improving the analysis and description of toxin-antitoxin systems (TAs) using both NGS data analysis to identify cut sites of some toxins, and public Tn-Seq data to identify new TAs. We began a new SNF project called "Evaluating items of scientific findings in cases where the defence says: ‘It is my twin brother’", together with groups at CHUV and the School of Criminal Sciences, Lausanne.

Main publications 2017

  • Rychener L et al. Clostridium chauvoei, an Evolutionary Dead-End Pathogen. Front Microbiol. 2017 Jun 9;8:1054. doi: 10.3389/fmicb.2017.01054. eCollection 2017.
  • Gros-Balthazard et al. The Discovery of Wild Date Palms in Oman Reveals a Complex Domestication History Involving Centers in the Middle East and Africa. Curr Biol. 2017 Jul 24;27(14):2211-2218.e8. doi: 10.1016/j.cub.2017.06.045.
  • Saavedra et al. Whole-Genome Sequence of a Colombian Acinetobacter baumannii Strain, a Coproducer of OXA-72 and OXA-255-Like Carbapenemases. Genome Announc. 2017 Feb 16;5(7). pii: e01558-16. doi: 10.1128/genomeA.01558-16.

Our main research topic:

Core facility and competence centre