What do we do?
Our main goal at the Laboratory for Biomolecular Modeling is to understand the physical and chemical properties of complex biological systems, in particular their function with regard to structure and dynamics. To this end, we use and develop a broad spectrum of computational tools, fully integrated with experimental data. Multiscale simulations and dynamic integrative modelling are used to investigate the function of molecular assemblies, mimicking the conditions of the native cellular environment.
Main publications 2017
- Tamò G et al. Disentangling constraints using viability evolution principles in integrative modeling of macromolecular assemblies. Sci Rep. 2017; 7(1):235
- Abriata LA et al. Signal Sensing and Transduction by Histidine Kinases as Unveiled through Studies on a Temperature Sensor. Acc Chem Res. 2017; 50(6):1359
- Reidenbach AG et al. Conserved Lipid and Small-Molecule Modulation of COQ8 Reveals Regulation of the Ancient Kinase-like UbiB Family. Cell Chem Biol. 2017