Tag: structural biology

  • A brief history of SIB

    With the creation of the SIB Swiss Institute of Bioinformatics in 1998, Switzerland made a historical move and positioned itself as a pioneer in the field of data science.

  • A look back on the 13th edition of [BC]2

    Last week, the 13th edition of the Basel Computational Biology Conference, co-organized by SIB Swiss Institute of Bioinformatics and the Biozentrum University of Basel, gathered over 500 participants from all over the globe. Among them,...

  • Andrea Cavalli's group

    What we do The overall objective of our research is to understand the role that structure and dynamics play in the definition of the function of biomolecules. In order to perform their function, proteins and other biological molecules undergo a...

  • Andrzej Stasiak's group

    What we do Using the mathematical concept of knotoids, we were able to characterize the topology of protein structures without the necessity of imposing a closure of analysed protein chains. New simulation approaches permitted us to emulate the...

  • Bart Deplancke's group

    What we do In the Laboratory of Systems Biology and Genetics (LSBG), we use high-throughput sequencing, single cell genomics, microfluidics, and computational approaches to decipher the regulatory code in Drosophila and mammals with a specific...

  • Bioinformatics, a Swiss pride - 20 years of service to the life sciences and health

    Whether we are retracing the history of our ancestors, designing new drugs or understanding what gives Swiss Gruyère its unique flavour, bioinformatics has become an essential discipline.

  • Bruno Correia's group

    What we do The Laboratory of Protein Design & Immunoengineering started in March 2015, at the EPFL. Currently, we have established both the computational and experimental branches of our research. Despite the short life of the LPDI we can...

  • Christian Ahrens' group

    What we do Our research revolves around the bioinformatic integration and analysis of datasets from state-of-the-art omics technologies, which we obtain through close collaboration with experimental biologists. These datasets include genome...

  • DNA loops and smoke rings have a lot in common

    Why do DNA loops forming different knot types sediment at different speeds? Researchers from SIB, UNIL and EPFL joined forces with Polish colleagues to answer this question.

  • DNA, a (hyper)winding road

    When it comes to packaging large amounts of information into tiny volumes, biology and physics often buddy up to reach creative solutions. The problem is even more complex with DNA, as the compacted information must also remain accessible to the...

  • Emmanouil Manolis Dermitzakis's group

    What we do Our group has a strong interest in population genomics and genetics of complex traits. We use various methodologies to understand the role of genetic variation in phenotypic variation and what fraction of genetic variation is harboured...

  • Evgeny Zdobnov's group

    What we do The group is active in the fields of comparative genomics and shotgun metagenomics. We study molecular evolution, develop approaches to genomics data analyses, and implement computational pipelines. We apply evolutionary models to...

  • Giovanni Ciriello's group

    What we do The Computational Systems Oncology lab integrates algorithmic design, numerical modelling, and molecular biology approaches to address relevant questions in cancer biology and therapeutics. We explore single and combinations of genetic...

  • Gunnar Rätsch's group

    What we do We are interested in modern machine-learning techniques suitable for the analysis of problems that arise in medicine and biology. In particular, we develop new learning techniques that are capable of dealing with large amounts of...

  • Laurent Falquet's group

    What we do In the Bioinformatics Unravelling Group of the University of Fribourg (BUGFri), we support life science researchers by providing expertise in data analysis of Next-Generation Sequencing (NGS) experiments, or any large-scale biological...

  • Marcel Riedi's group

    What we do In the Service and Support for Science IT (S3IT) unit, we provide support for science in general, and for life science and medicine in particular. S3IT serves as a partner for both local and national projects to enable competitive...

  • Matteo Dal Peraro's group

    What we do Our main goal at the Laboratory for Biomolecular Modeling is to understand the physical and chemical properties of complex biological systems, in particular their function with regard to structure and dynamics. To this end, we use and...

  • Much like the khipu system, DNA knots contain precious information

    Khipu – or knotted strings – were used by several Andean cultures to record information. Similarly, knots in DNA can reveal a lot about the molecule’s 3D organisation...

  • Olivier Michielin - Vincent Zoete's group

    What we do The Molecular Modelling Group studies molecular interactions using modelling techniques such as homology modelling, molecular dynamics, docking and free energy simulations. Our main activity consists in developing and applying methods...

  • Our annual activity report, the SIB Profile 2018, is out

    The new edition of the SIB Profile celebrates the 20 years of the Institute (1998-2018).

  • Our latest video: ‘Swiss Bioinformatics: more than data’

    Discover the spirit behind Switzerland’s vibrant community of scientists dedicated to making sense out of biological data...

  • Philipp Bucher's group

    What we do In the Computational Cancer Genomics Group, we are interested in gene regulation in both healthy and diseased cells. Breakthroughs in genomics technologies have led to the production of large volumes of data that could potentially tell...

  • Precision medicine and the role of bioinformatics: four short films to understand

    Bioinformatics is fundamental to precision medicine. But why? How do hospitals and researchers benefit from bioinformatics to help patients? Canal9 TV Channel, the Oncology department of UNIL/CHUV and SIB all set out together to find answers to...

  • Robert Waterhouse's group

    What we do The group’s research is focused on elucidating interactions between gene evolution and gene function through developing computational approaches to interrogate evolutionary and functional genomics data. We are developing quantifications...

  • SIB core resources

    A stringent selection process SIB's External Scientific Advisory Board (SAB) is in charge of providing recommendations on the selection of SIB’s core resources every four years. Assessing competitive criteria, including the scientific impact and...

  • SIB Days 2018: Swiss Bioinformatics connected

    Hundreds of SIB Members from across Switzerland came to Biel/Bienne on 26 June to attend the SIB Days – our 2-day internal conference and a unique opportunity for the bioinformatics community to connect.

  • SIB Group paves a new way to analyse protein knots

    Some proteins form a specific knot when they fold into their native structures. The function of knots in proteins and the mechanism of their formation are still poorly understood. In order to study protein knots, it is necessary to identify knotted...

  • SIB IN THE NEWS: DRUG DESIGN AND OUTREACH

    Today in the national news, Marie-Claude Blatter (Responsible - SIB Outreach activities) and Vincent Zoete (Associate director - Molecular Modelling group) presented SIB's role in drug design and bioinformatics outreach on the Radio Télévision...

  • Supercoiling pushes molecular handcuffs along chromatin fibres

    As it squeezes down the chromatin fibre, the cohesin protein complex extrudes a growing loop of DNA - a bit like the quick-lacing system of trail-running shoes. But what is powering the movement of the protein?

  • The new SIB Profile is out

    The last year has been full of developments for SIB, from biocuration, with SIB hosting the 9th International Biocuration Conference, to several projects in personalized health and many more scientific advances...

  • Torsten Schwede's group

    What we do In the Computational Structural Biology (CSB) Group, we focus on the development of methods and algorithms to model, simulate and analyse three-dimensional protein structures and their molecular properties in order to apply these...

  • Vincent Zoete's group

    What we do The laboratory specializes in the development of computer-aided algorithms, programs and databases for protein engineering and drug design, with applications in oncology, notably in immunotherapy of cancer. We also provide support in...

  • Vital-IT

    What we do With a multidisciplinary team of scientists and technical staff, Vital-IT maintains a competency centre in bioinformatics and computational biology. Its infrastructure currently spreads across six institutions that maintain...

  • Vital-IT group

    What we do With a multidisciplinary team of scientists and technical staff, at Vital-IT we maintain a competenc ecentre in bioinformatics and computational biology. Our infrastructure currently spreads across six institutions that maintain...