Tag: population genetics

  • A genome under influence: The faulty yardstick in genomics studies and how to cope with it

    References form the basis of our comprehension of the world: they enable us to measure the height of our children or the efficiency of a drug. But when such yardsticks are faulty, doubts are cast on all the measurements that derive from them.

  • Anna-Sapfo Malaspinas's group

    What we do Ancient and modern DNA research have both entered the genomics era. At the Evolutionary Genomics Group (EGG), we aim to characterize evolutionary processes (genetic drift, natural selection, migration and mutation) while relying on...

  • April Virtual Seminar by Sara Mitri: an interview

    From robots to microbes, a logical stepIf you have a deep understanding of how cells interact, then you can pilot these interactions to the benefit of the cells, the environment or even human health. Sara Mitri - SIB Group Leader at the Department...

  • Daniel Wegmann's group

    What we do When observing nature, it is easy to be impressed by the huge diversity seen on any biological scale. Our primary aim is to better understand the underlying evolutionary and ecological processes that have been shaping this diversity...

  • Emmanouil Manolis Dermitzakis's group

    What we do Our group has a strong interest in population genomics and genetics of complex traits. We use various methodologies to understand the role of genetic variation in phenotypic variation and what fraction of genetic variation is harboured...

  • Erik van Nimwegen's group

    What we do Our main research interest in the Genome Systems Biology (GSB) Group is the study of genome-wide regulatory systems, in order to reconstruct them from high-throughput molecular data, understand and model how they have evolved, and...

  • February Virtual Seminar by Jérôme Goudet: an interview

    Simulating past demography: can it be done?Is it possible to infer the ancestral demography of a species from genetic data, based on its current genetic composition? "Yes," answers Jérôme Goudet, SIB Group Leader and associate professor in...

  • Harmful mutations and range expansion: computers got it right

    Organisms that are expanding their spatial range suffer from a drastic decrease of fitness over time due to the accumulation of harmful mutations. A study led by a team of scientists from the SIB Swiss Institute of Bioinformatics and the University...

  • How species arise: a mathematical answer

    Predicting when and how species arise is now possible with a new theoretical model using genome-wide data, developed by SIB researcher Simon Aeschbacher and colleagues. The study was published yesterday in the Proceedings of the National Academy of...

  • Jérôme Goudet's group

    What we do Our group's interest is focused on understanding how the interplay of population structure, trait architecture and selection can be disentangled. To this end, we use different approaches, from theory and the development of statistical...

  • June Virtual Seminar by Matt Robinson: an interview

    Predicting diseases, one step aheadOur health depends not only on the genes that Nature dealt us at birth, but also on the environment we evolve in and the kind of life we lead.

  • Laurent Excoffier's group

    What we do In the Computational and Molecular Population Genetics (CMPG) Group, we develop new methodologies for the simulation and analysis of molecular polymorphisms within species, with a particular focus on humans. We also develop and maintain...

  • Matthew Robinson's group

    What we do We develop and apply statistical methodologies to large human phenotype-genotype datasets, to address long-standing questions in population and quantitative genetics. These have improved the prediction accuracy of disease risk in...

  • Paleogenomics suggest inbreeding avoidance in early humans

    Were our prehistoric ancestors aware of the dangers caused by procreation among close relatives? A study led by an international team of scientists, including SIB Swiss Institute of Bioinformatics Group Leader Laurent Excoffier and his team at the...

  • The genetic burden of pioneers

    Having a pioneer ancestor could explain the excess of harmful mutations observed in recently colonized areas of Quebec, a recent study shows. Using a unique combination of genomic and historical data, researchers from SIB at the University of Bern,...

  • Zoltán Kutalik's group

    What we do In the Statistical Genetics Group, we are interested in the development of statistical methodologies in order to decipher the genetic architecture of complex human traits related to obesity. To do this, we efficiently combine...