What do we do?
At the Evolutionary Systems Biology Group we study the evolution and evolvability of biological systems at all levels of biological organization, from genes and genomes to biological networks and whole organisms. We develop bioinformatics tools to integrate data from a variety of sources, including comparative whole-genome sequence data, microarray expression data, and high-throughput protein interaction data. Our work uses comparative analysis of genomic data, laboratory evolution experiments and mathematical modelling. We also develop a variety of bioinformatics tools to help us take advantage of the torrent of data in genomics and structural biology.
Main publications 2015
- Bilgin Sonay T et al. Tandem repeat variation in human and great ape populations, and its impact on gene expression divergence. Genome Res 2015;25(11):1591-9.
- Bratulic S et al. Mistranslation drives the evolution of robustness but not translational accuracy in TEM-1 β-lactamase. Proc Natl Acad Sci 2015;112(41):12758-63.
- Hayden E et al. Intramolecular phenotypic capacitance in a modular RNA molecule. Proc Natl Acad Sci 2015;112(40):12444-9.
- Hosseini S-R et al. Exhaustive analysis of a genotype space comprising 1015 central carbon metabolisms reveals an organization conducive to metabolic innovation. PLOS Comput Biol 2015;11(8):e1004329.