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Marc Robinson-Rechavi
Evolutionary Bioinformatics Group
University of Lausanne
Group Webpage

What do we do?

At the Evolutionary Bioinformatics Group we are mainly concerned with determining the role of evolutionary innovation and constraint in animals. For this, we develop methods and databases to extract reliable information from genome and transcriptome data. These databases include Bgee, a database for gene expression evolution, Selectome, a database of positive selection. In developing these resources, we also conduct research on ontologies, biocuration, and high-performance computing. Our biological focus is to link Evo-Devo with phylogenomics. We notably study the role of gene duplication in divergence between genes and between species.

Highlights 2016

We added a new gene page to our Bgee database of gene expression evolution. Thanks to a new algorithm ranking expression information of different types, from RNA-seq to in situ hybridization, we are able to present first the most relevant expression patterns for a gene, even when it is expressed in hundreds of conditions.

We have also distributed an R package allowing to access all Bgee data and to perform TopAnat computations. A manuscript describing it is in preprint at F1000research Bioconductor channel.

The group has participated in a new paper resulting from the master’s degree course “Sequence a genome”, a course during which master’s degree students sequence, assemble and annotate new bacterial genomes, for the first time using PacBio and RNA-seq. The paper is based directly on the students’ work during the class.

Main publications 2016

Our research topics: