Biological macromolecules such as DNA and proteins acquire a specific architecture in space. The 3D conformation they adopt is a direct consequence of their nucleic acid or amino acid sequence, respectively. A protein’s function is defined by its 3D structure.
Bioinformatics develops software that is able to model and predict a protein’s 3D structure, and hence deduce its probable function. Such tools are of great assistance in the field of drug design, for instance.
At SIB, several groups are working on the topic structural biology
as their main field of activity:
as one field among others: