Common breast cancer mutation induces multipotency and tumour heterogeneity

Understanding how different cell populations arise within a tumour – so-called tumour heterogeneity – is widely regarded as a major challenge for cancer biology.

Mohamed Bentires-Alj and his group at the FMI have discovered how the most frequent mutation in human breast cancer leads to tumour heterogeneity. The PI3-kinase mutation forces cells back into a dedifferentiated, stem-like state from which tumours containing cells of various lineages can develop. These results have been published in Nature.
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