What do we do?
At the Genomics of Complex Traits Group we have a strong interest in population genomics and genetics of complex traits. We are using various methodologies to understand the role of genetic variation in phenotypic variation. We also aim to understand what fraction of genetic variation is harboured within functional elements of the human genome. Our main focus is on genome-wide analysis of gene expression and cellular phenotypes and their association with nucleotide variation. We attempt to detect functional genetic variation in regulatory elements and subsequently use functional variation and accurately measured gene expression variation to bridge the genotype with disease phenotypes in association studies.
During this past year we have engaged in large-scale analysis of GTEx data, multi-omics cohort data and system genetics analysis, and produced a number of manuscripts that are on their way for publication. Our group has also moved to cancer genomics more intensively with a focus on the contribution of non-coding regulatory DNA to cancer predisposition and progression.
Main publications 2016
- Ongen H, et al. Fast and efficient QTL mapper for thousands of molecular phenotypes. Bioinformatics. 2016 May 15;32(10):1479-85. doi: 10.1093/bioinformatics/btv722.
- Glastonbury CA, et al. Adiposity-Dependent Regulatory Effects on Multi-tissue Transcriptomes. Am J Hum Genet. 2016 Sep 1;99(3):567-79. doi: 10.1016/j.ajhg.2016.07.001.
- Lotta LA, et al. Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance. Nat Genet. 2017 Jan;49(1):17-26. doi: 10.1038/ng.3714.