What do we do?
Our focus at the Computational Oncogenomics Group is the analysis of structural variations in cancer genomes using computational genomics, including bioinformatics and systems biology methods. Our work centres around our collections of molecular tumour data, assembled from genomic screening experiments in cancer e.g. through comparative cytogenetic hybridization (CGH) and genome sequencing studies. Specific projects deal with the development of computational methods for structural data analysis, genomic analyses in selected tumour entities as well as with the large-scale exploration of genomic patterns across malignancies.
In 2015, much of the group’s activity was focused on advancing projects for the Global Alliance for Genomics and Health (GA4GH). In particular, we contributed to GA4GH schema elements for the exchange of data describing biological and clinical features. Additionally, our team designed a GA4GH data implementation project which has been accepted as one of the ELIXIR human data pilot studies and will be executed in 2016. Towards the end of 2015, the group started a new, major data acquisition round for the next version of the arrayMap repository.
Main publications 2015
- Muff R et al. Genomic instability of osteosarcoma cell lines in culture: impact on the prediction of metastasis relevant genes. PLOS ONE 2015;10(5):e0125611.