What do we do?
At the CALIPHO Group, which stands for “Computer and Laboratory Investigation of Proteins of Human Origin”, we aim to use a combination of bioinformatics and experimental methodologies to increase the knowledge about the function of the 20,000 or so protein-coding genes that exist in the human genome. Our main mission is the development of neXtProt, a human protein knowledge resource. Recently, we have focused on annotating the effects of human protein variations in the context of cancers and genetic diseases, and analysing results of high-throughput experiments to shed light on the function of selected sets of uncharacterized human proteins.
In 2015, our team was particularly active in the continued development of our new advanced search: search.nextprot.org/. Based on SPARQL/RDF technology it allows the user to make very precise queries across the wealth of knowledge stored in neXtProt as well as other resources that also use SPARQL.
Our team also continued our efforts in the annotation of the effect of protein variations in cancers and diseases, with an emphasis on sodium channel proteins, a family of proteins involved in many types of epilepsies as well as other genetic diseases.
Main publications 2015
- Desmurs M et al. C11orf83, a mitochondrial cardiolipin-binding protein involved in bc1 complex assembly and supercomplex stabilization. Mol Cell Biol 2015;35:1139-1156.
- Gaudet P et al. The neXtProt knowledgebase on human proteins: current status. Nucleic Acids Res 2015;42:D764-D770.
- Holliday GL et al. Key challenges for the creation and maintenance of specialist protein resources. Proteins 2015;83:1005-1013.